Tissue Implantation

The chart below lists some of the types of reconstructive surgeries such as orthopedic, neurologic, cardiovascular, spinal, ophthalmologic, and sports medicine that might utilize human tissue. The chart also includes tissue grafts normally used for these surgeries:

Type of Surgery

Surgical Procedure

Tissue Products

Orthopedic

Total Hip Revision

Cortical Bone

Non Union

Cancellous bone chips

Bone Tumor Reconstruction

Osteoarticular bone

Neurologic

Craniotomy

Fascia, pericardium

Spinal

Cervical Diskectomy/Fusion

Ulna, radius, fibula

Lumbar Diskectomy & fusion

Femur ring

Cardiovascular

Valve Replacement

Aortic, Pulmonary or Mitral Heart Valve

Access Surgery

AV Shunt

Femoral Vein

Sports Medicine

ACL, PCL

Tendon

Ophthalmologic

Cornea Transplant

Cornea

Enucleation

Sclera

Podiatric

Ulcers

Apligraf, Dermagraft, Skin

Tissue Safety

There is a very small, if not negligible, risk that an allograft tissue can transmit a disease or infection.

This is rare due to the processing and testing of the tissue. Here are some of the steps taken to minimize any chance of this occurring:

  1. Donor medical history
  2. Donor physical assessment
  3. Donor Serological testing (See explanation below.)
  4. Donor Autopsy results if available
  5. Cleaning and processing of all tissues under aseptic conditions
  6. Cultures of each tissue at recovery and processing
  7. Sterile packaging and monitored storage of processed tissues

Donor blood samples are tested by a specially licensed testing facility for Hepatitis B Antigen/Antibody, Hepatitis C Antibody, and Human Immunodeficiency Virus 1 and 2 (AIDS) as required by the FDA. Both, Musculoskeletal Transplant Foundation and Cryolife, Inc. exceed the FDA requirements for serological testing. All tests must be negative for tissues to be released.