See also
Antibiotics (General) Amoxicillin is a relative of the antibiotic penicillin, but has been modified to have a broader spectrum of effect. Possible Helpful Interaction According to two studies, the supplement bromelain (from pineapple stems) may increase the absorption of amoxicillin.1,2
This effect might help the antibiotic work better.
Possible Nutritional Depletion There are concerns that antibiotic treatment might reduce levels of vitamin K in the body. However, this effect seems to be slight, and only significant, if at all, in individuals who are already considerably deficient in vitamin K.3–6
Tinozzi S and Venegoni A. Effect of bromelain on serum and tissue levels of amoxicillin.
Drugs Exp Clin Res
4: 39–44, 1978.
Luerti M and Vignali M. Influence of bromelain on penetration of antibiotics in uterus, salpinx and ovary.
Drugs Exp Clin Res
4: 45–48, 1978.
Cohen H, Scott SD, Mackie IJ, et al. The development of hypoprothrombinaemia following antibiotic therapy in malnourished patients with low serum vitamin K
1
levels.
Br J Haematol
68: 63–66, 1988.
Conly J and Stein K. Reduction of vitamin K
2
concentrations in human liver associated with the use of broad spectrum antimicrobials.
Clin Invest Med
17: 531–539, 1994.
Shearer MJ, Bechtold H, Andrassy K, et al. Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status.
J Clin Pharmacol
28: 88–95, 1988.
Goss TF, Walawander CA, Grasela TH, et al. Prospective evaluation of risk factors for antibiotic-associated bleeding in critically ill patients.
Pharmacotherapy
12: 283–291, 1992.
Last reviewed July 2012 by EBSCO CAM Review Board Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved. |
|
 |
Physicians & Related Services |
|
|
|
|