| Risk Factors
Cirrhosis is a disease in which the liver becomes permanently damaged and the normal structure of the liver is changed. Healthy liver cells are replaced by scarred tissue. The liver is not able to do its normal functions, such as detoxifying harmful substances, purifying blood, and making vital nutrients.
In addition, scarring slows down the normal flow of blood through the liver, causing blood to find alternate pathways. This may result in bleeding blood vessels known as gastric or
Cirrhosis of the Liver
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Causes of cirrhosis include:
Excessive consumption of
B, and D
- Autoimmune hepatitis
Inherited diseases, such as
glycogen storage disease,
Nonalcoholic steatohepatitis (NASH), associated with:
Bile duct blockages, associated with:
- Congenital defects
- Scarred ducts—sometimes related to inflammatory bowel disorders
- Gallbladder surgery
Drugs and toxins:
- Heart failure, causing blood to repeatedly back up into the liver
Factors that may increase your chance of having cirrhosis include:
Cirrhosis often does not cause symptoms early in the disease process. Symptoms start when the liver begins to fail, as scar tissue replaces healthy cells. Symptom severity depends on the extent of liver damage.
Cirrhosis may cause:
- Poor appetite, nausea, or weight loss
- Abdominal swelling, tenderness, and pain
- Appearance of thin, purplish-red, spidery looking blood vessels on the skin
- Menstrual problems
- Enlarged breasts in men
As cirrhosis progresses, it may cause:
—yellowing of the skin and whites of the eyes
- Dark urine
- Water retention and swelling in the legs and abdomen
- Enlarged liver or spleen
- Loss of body hair
- Bleeding and bruising
- Vomiting blood
- Neurological problems, such as forgetfulness, confusion, agitation, or tremors
- Inability to process medications
Complications of cirrhosis may include:
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Tests may include:
Other tests may include:
- Inserting a catheter into the liver vein and measuring the pressure within that vein; rarely necessary
- Removing fluid from the abdomen and examining it
- Other tests to determine what caused the cirrhosis and what complications may occur
There is no cure for cirrhosis. The goals of treatment are to keep the condition from getting worse, including:
- Control the cause
- Treat underlying medical conditions
- Prevent additional damage
- Treat symptoms and complications
- Liver cancer screenings
Talk with your doctor about the best treatment plan for you. Options include:
Doctors prescribe drugs to:
- Treat hepatitis and complications that arise
- Reduce the absorption of waste products and toxins in the digestive system
- Reduce the risk of a blood vessel-breaking
- Fight infections
- Shed excess fluids
—may be done if:
- Complications can no longer be controlled using medical therapy
- The liver stops functioning
—This is used to tie off bleeding blood vessels (varices) or to inject drugs to cause clotting. A thin tool with a lighted tip is inserted down the throat to help the doctor see and access the varices, which are located in the esophagus.
- Stop drinking alcohol completely.
- Do not take any medications without your doctor's approval, including over-the-counter drugs.
balanced diet. Choose a variety of fruits and vegetables, as well as lean proteins, like beans and poultry.
- If your liver disease is more advanced, you may need to limit protein intake, because your weakened liver will not be able to process it properly.
- You may need to limit salt in your diet, because it increases water retention.
- Take any vitamin supplements your doctor recommends.
- Put your feet and legs up to decrease swelling.
Due to increased risk of infections, take these steps:
Getting vaccines for
pneumonia, and hepatitis
- Avoiding raw seafood
- Avoiding people who are sick with communicable diseases, like the flu or common cold
- Washing your hands often
If you are diagnosed with cirrhosis, follow your doctor's
To help reduce your chance of developing cirrhosis, take these steps:
- Drink alcohol in moderation. Moderate alcohol intake is no more than two drinks per day for men and one drink per day for women.
- Get hepatitis vaccines.
to lower your chance of getting hepatitis B.
- If you use IV drugs, do not share needles, which can spread hepatitis B, C, or D.
- Maintain a healthy weight.
- Follow your doctor's recommendations about blood tests when taking medications that may damage the liver.
American Academy of Family Physicians.
Information from your family doctor. Cirrhosis and chronic liver failure: what you should know. Am Fam Physician. 2006;75(5):781.
National Institute of Diabetes and Digestive and Kidney Diseases website. Available at:
http://digestive.niddk.nih.gov/ddiseases/pubs/cirrhosis. Updated February 21, 2012. Accessed August 28, 2013.
Cirrhosis of the liver. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed.ebscohost.com/about/about-us. Updated July 19, 2013. Accessed August 28, 2013.
Hirschfield GM, Gershwin ME. Primary biliary cirrhosis: one disease with many faces.
Isr Med Assoc J. 2011;13(1):55-59.
Molodecky NA, Kareemi H, Parab R, Barkema HW, Quan H, Myers RP, Kaplan GG.
Incidence of primary sclerosing cholangitis: a systematic review and
Understanding cirrhosis of the liver. American Gastroenterological Association website. Available at:
http://www.gastro.org/patient-center/digestive-conditions/cirrhosis-of-the-liver. Accessed August 28, 2013.
2/12/2010 DynaMed's Systematic Literature Surveillance
https://dynamed.ebscohost.com/about/about-us: Chang Y, Ryu S, Sung E, et al. Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men.
Last reviewed September 2013 by Kim Carmichael, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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